Rs1042779

(A;A) (A;G) (G;G)

[PMID 19416921] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Published 2009. Found that "The most strongly associated nonsynonymous SNP rs1042779 (OR = 1.19, P = 1.8 × 10−7) is in the ITIH1 gene on chromosome 3, with other strongly associated nonsynonymous SNPs in GNL3, NEK4, and ITIH3." In particular, "Four additional nonsynonymous SNPs in this region had P < 10−5: rs2289247 (Val367Met) and rs11177 Arg27Gln in GNL3 (guanine nucleotide binding like-3), rs1029871 (Pro225Ala) in NEK4, and rs3617 (Gln315Lys) in ITIH3."

[PMID 20081856] Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.. Published 2010. In reference to the 2009 research article cited [PMID 19416921], "the most significant SNP in that study was nominally significant in the present study (rs1042779; p=0.001).

[PMID 19416921] 유럽 조상의 개인에서 조울증(양극성 장애)에 대한 genome-wide association 과 메타분석.

[PMID 20081856] Genome-wide association data의 메타분석을 통한 3p21.1의 주요 우울증에대한 위험 유전자자리의 발견.

[PMID 24389398] 중국 한족 인구에서 ITIH Family Genes 는 조현병(정신분열증)과 주요 우울증의 위험을 준다.

[PMID 19416921] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.

[PMID 20081856] Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1

[PMID 24389398] ITIH Family Genes Confer Risk to Schizophrenia and Major Depressive Disorder in the Han Chinese Population