List of large-scale genotype and phenotype association study projects

From Variome

List of large-scale genotype and phenotype association study projects

1) List
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gap
 

2) SHARe

Source: http://public.nhlbi.nih.gov/GeneticsGenomics/home/programs.aspx
SHARe: SNP Health Association Resource
Program Description
The NHLBI SHARe Project will conduct genome wide association studies and analyses in several large NHLBI Cohort studies to identify genes underlying cardiovascular and lung disease and other disorders like osteoporosis and diabetes. The first SHARe cohort is the Framingham Heart Study, in which genotyping of 550,000 SNPs has been completed in over 9,000 subjects from three generations. The NIH National Center for Biotechnology Information is developing and housing the database for this research project in its Database for Genotype and Phenotype (dbGaP). Data will be available at no cost to all qualified investigators via an application process involving an NHLBI Data Access Committee.
The NHLBI Program Officer for SHARE is Cashell Jaquish, Ph.D.
Related Websites:
NHLBI Whole Genome Association at NCBI
Program Start and End Date
April 2006 to August 2009
Original Funding Announcement (FOA)
SNP Health Association Resource (SHARe)
NHLBI-PB-2006-091
The NHLBI Program Officer for SHARE is Cashell Jaquish, Ph.D.

3) CARe
 CARe: Candidate-gene Association Resource
 Program Description
The NHLBI initiated the Candidate gene Association Resource (CARe) to create a shared genotype/phenotype resource for analyses of the association of genotypes with phenotypes relevant to the mission of the NHLBI. The resource comprises nine cohort studies funded by the NHLBI: Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Cleveland Family Study (CFS), Coronary Artery Risk Development in Young Adults (CARDIA), Cooperative Study of Sickle Cell Disease (CSSCD), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Multi-Ethnic Study of Atherosclerosis (MESA), and the Sleep Heart Health Study (SHHS). A database of genotype and phenotype data will be created that includes records for approximately 50,000 study participants with approximately 50,000 SNPs from more than 1,200 selected candidate genes. In addition, a genome wide association study using a 1,000K SNP Chip will be conducted on approximately 9,500 African American participants drawn from the 50,000 participants in the nine cohorts. When completed, access to the CARe database will be provided to the broad scientific community for research purposes approved by the NHLBI Data Access Committee. A single contract award was made to the Broad Institute for they genotyping and bioinformatics center; Dr. Stacey Gabriel is the Principal Investigator.
The NHLBI Program Officer for CARe is Richard Fabsistz, Ph.D.
Related Websites:
NHLBI CARe Center Home Page

Projects
 • ARIC - Atherosclerosis Risk in Communities
 • CARDIA - Coronary Artery Risk Development in Young Adults
 • CFS - Cleveland Family Study
 • CHS - Cardiovascular Health Study
 • CSSCD - The Cooperative Study of Sickle Cell Disease
 • FHS - Framingham Heart Study
 • JHS - Jackson Heart Study
 • MESA - Multi-Ethnic Study of Atherosclerosis
 • SHHS - Sleep Heart Health Study 

Program Start and End Date
April 2006 to March 2010
Original Funding Announcement (FOA)
Large-Scale Genotyping of NHLBI Cohorts 
RFP-HC-06-03

4)  Data distribution policy : dbGaP

dbGaP Overview
  - The database of Genotype and Phenotype (dbGaP) was developed to archive and distribute the results of studies that have investigated the interaction of genotype and phenotype.
  - dbGaP provides two levels of access - open and controlled
  - Controlled-access data can only be obtained if a user has been authorized by the appropriate Data Access Committee (DAC).
dbGaP Access to Individual-Level Data
  - Request to Download Individual-Level Data from dbGaP Authorized Access
  - Data Use Certification Requirements (DUC)
  - Release Date for Individual-Level Data: October 01, 2007
  - Embargo Release Date: February 01, 2009

- Use Restrictions
 Consent Groups
 General Research Use
 The informed consent document signed by the Framingham Heart Study Participants allows use of these data by investigators employed by non-profit and for-profit organizations. These data may be used by private companies in the development of diagnostics and therapeutics under the current consent.
 This consent group requires IRB approval
 Participant set: 6907
 Non-profit Use
 The informed consent document signed by Framingham Heart Study participants allows use of these genetic data by investigators employed by non-profit organizations only. Direct use of these data by private companies to develop diagnostics or therapeutics is not allowed under the current consent.
 This consent group requires IRB approval
 Participant set: 7354
 No permitted use
 This data set phs000007.v2.p1.c3 (SHARe Framingham) is composed of 0 individuals who have withdrawn ALL consent for use of their data in research. All Authorized users of phs000007 are directed to review this file and remove all phenotype and/or genotype data for these individuals from your local copy of these data.
 This consent group requires IRB approval
 Participant set: 0